Acute Lymphoblastic Leukemia with Aberrant T-Cell Immunophenotype in a Dog: A Case Report

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Authors

  • Fernanda Regina da Silva FCAV - Unesp
  • Rafael Costa Bitencourt FCAV - Unesp
  • Laura Campos Cassavia Cintra de Oliveira FCAV - Unesp
  • Gabriel Henrique Crippa FCAV - Unesp
  • Andrigo Barboza de Nardi FCAV - Unesp

DOI:

https://doi.org/10.3738/21751463.4564

Abstract

Acute lymphoblastic leukemia (ALL) is a rare hematological neoplasm characterized by the disordered proliferation of lymphoblasts in the bone marrow and subsequent release into peripheral blood. This report describes the case of an 8-year-old German Shepherd diagnosed with ALL with an aberrant T-cell immunophenotype (CD3+/CD4-/CD8-/CD34+). The diagnosis was confirmed by flow cytometry, following laboratory results indicating extreme leukocytosis (90,500 leukocytes/μL) and 99% atypical lymphocytes. Palliative treatment with prednisone (2 mg/kg/day) and chlorambucil (Leukeran®) (6mg/m²/orally/once daily) was instituted to manage clinical signs, resulting in a reduction of circulating atypical lymphocytes. ALL is a biologically aggressive and rapidly progressing neoplasm. This report highlights the importance of early identification of ALL and the use of advanced techniques such as flow cytometry for the diagnosis and prognosis of these types of neoplasms.

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Published

2025-06-16

Issue

II SIMCAVET - Edição Especial

Section

II SIMCAVET - Edição Especial

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